A UFC Heavyweight Championship bout between Francis Ngannou and Present champion Stipe Miocic Functioned as If headliner.
The episode also featured a UFC Light Heavyweight Championship bout between present champion Daniel Cormier and Volkan Oezdemir. 
A welterweight bout between The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner Kamaru Usman and Emil Weber Meek was originally scheduled for UFC 219. However, due to an alleged visa dilemma for Meek which influenced his traveling schedule, the pairing was postponed and then rescheduled to this particular occasion.  However, it was shifted to UFC Fight Night: Stephens vs. Choi per day later, that took place six days prior to this event. 
A welterweight bout between Abdul Razak Alhassan and Sabah Homasi was originally scheduled for UFC 219, but later altered to this occasion. When Alhassan acquired via a TKO, the pairing met at UFC 218. 
Charles Rosa was expected to face novice Dan Ige. However, on December 22, Rosa pulled out injury.  Ige remained on the card and confronted fellow newcomer Julio Arce. 
Arnold Allen was anticipated to face The Ultimate Fighter: Latin America 2 lightweight winner Enrique Barzola at the occasion. However, Allen was pulled from the struggle on January 11 due to alleged visa issues which restricted his ability to travel.  He had been replaced by novice Matt Bessette that is promotional. 
Jamie Moyle was anticipated to face Maryna Moroz in the event. However, Moyle pulled from the struggle during the week leading up to the event citing an undisclosed injury.  In turn, advertising officials indicated that Moroz would be rescheduled for a future occasion.
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